Amounts used in studies
Melanotan 2 Dosage figures are study facts, not directions
You can see what each study used and why none of it is a dose to copy.
Every amount belongs to one study
A Melanotan 2 dosage number may look like advice, though it isn't. This page tells you only how each study was run. No approval permits Melanotan 2 use in people anywhere [3]. Nothing below directs you to take it.
For example, one trial used 0.025 milligrams per kilogram. The person's weight set the total. Researchers injected that amount into the layer under the skin. The figure records what the trial did; it gives you no dose to copy. Some animal studies placed the compound inside the brain. Those animal amounts don't fit human use.
Two small human studies used shots under the skin
Two small early Melanotan 2 studies provide the human facts. One skin study enrolled 3 men. During two weeks, the study raised the amount from 0.01 to 0.025-0.03 milligrams for each kilogram the man weighed. Researchers gave shots below the skin on alternate weekdays. At 0.03 milligrams per kilogram, sleepiness stopped any further increase. The authors suggested daily tests at 0.025 milligrams per kilogram. The total amount would change with body weight. They said more small safety studies had to come next [1].
A second study involved 10 men with erection trouble. Each man received 0.025 milligram per kilogram of his weight, as one injection under the skin [2]. These figures record only what the studies used. No later study with more people produced an approved dose [3].
Animal studies used amounts that don't fit human use
Animal studies asked other questions and used other methods. In one hunger study, mice received 0.1, 0.3, or 1 nanomole. A nanomole is a very small lab amount. Researchers put it in a small area of the mouse brain linked with reward [5]. Other rat work also placed it inside the brain [10].
A separate rat test found that 4.6% of the swallowed amount reached the blood [7]. None of these figures gives you a dose for people. They show only how the animal tests were run.
Melanotan 2 injections were given in several ways
Both human studies placed Melanotan 2 injections into tissue under the skin [1], [2]. People who used the compound on their own also report shots there. Some rat studies put it into a vein [9]. Other reports mention unlicensed sprays used through the nose.
When rats swallowed it, about 4.6% of the amount reached their blood [7]. That helps explain why shots appear so often. Yet an unknown vial brings added danger. Doctors have reported a painful erection, kidney damage, and severe muscle breakdown after self-use [4], [25].
Melanotan 2 half life in people is still unknown
Researchers haven't found a sound human measure of the Melanotan 2 half-life. Half-life tells you how long the blood level takes to fall by half. In rats, the compound left the blood quickly and in several stages [41]. Scientists also studied a close drug in people; it moved into and out of the blood quickly. Even so, its timing can't answer the question for this compound.
Your skin can stay darker after the compound is gone from your blood. Your skin may go on adding pigment after the compound is gone. Your tan or mole changes may therefore remain for weeks. The Melanotan 2 effects page describes slow and uneven fading reported by users.
Lab reports say cold and dry storage slows breakdown
Lab reports describe Melanotan 2 as a freeze-dried powder. Cold, dry conditions helped the powder last longer. Mixed liquid was often held near 4 °C, close to the temperature inside your refrigerator. Its parts join end to end in a ring. This form is harder for enzymes to break apart. Enzymes are proteins that help break down the body's hormone [7]. These facts aren't mixing or storage directions for your home.